ICanEmail

A simple, but powerful, full-screen, talking email program.  Designed for
those with cognitive challenges, visual challenges, as well as physical
challenges. For the user, it operates in a sequential manner, where it asks
one question at a time, such as "Who would you like to send this to?" or "If
you'd like to speak your message, you can do that here."  

Read the entire description at:
http://www.rjcooper.com/icanemail/