L&H Kurzweil 3000 for the Mac

L&H Kurzweil 3000 reads scanned or electronic text aloud using human sounding
synthetic speech (L&H RealSpeak). Words are highlighted in contrast as they
are spoken. This patented auditory and visual presentation of information
helps increase reading accuracy, speed, and comprehension for struggling
readers. 

http://www.lhsl.com/kurzweil3000/mac/
http://www.lhsl.com/realspeak/